QS 11 ( QS11; QS-11; QS 11 )

Catalog No. M17682 CAS No. 944328-88-5

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Product Name

QS 11
Note

Research use only, not for human use.
Brief Description

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor.
Description

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
Synonyms

QS11; QS-11; QS 11
Pathway

Angiogenesis
Target

CDK
Recptor

ARFGAP1
Research Area

——
Indication

——

CAS Number

944328-88-5
Formula Weight

567.7
Molecular Formula

C36H33N5O2
Purity

98%
Solubility

DMSO : ≥ 100 mg/mL 176.16 mM; H2O : < 0.1 mg/mL
SMILES

OC[C@H](Cc1ccccc1)Nc1c2c(n(Cc3ccc(c4ccccc4)cc3)cn2)nc(Oc2ccc3CCCc3c2)n1
Chemical Name

(2S)-2-[[2-(2,3-Dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino]-3-phenylpropan-1-ol

1. Emre N., et al. A chemical approach to stem cell biology. Curr Opin Chem Biol. 2007 Jun;11(3):252-8.

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